QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by O'Neal, R. M. Articles by Hartroft, W. S. Search for Related Content PubMed Articles by O'Neal, R. M. Articles by Hartroft, W. S.

Increased Lipotropic Requirements with Renal Necrosis Induced in Rats by High-Fat Diets^1,2,

Department of Pathology, Washington University School of Medicine, St. Louis, Missouri

In weanling rats a high-cholesterol diet provides a sensitive indicator for the effect of various dietary fats on choline requirement.

Our results indicate that under these conditions cocoa butter increased choline requirement markedly, whereas butter did not. This effect was not the result of saturation of fat, as corn oil is almost as effective as cocoa butter. A lipotropic effect of sodium cholate was observed in these experiments.

High-fat and high-cholesterol diets used in other experimental studies must be formulated with care because even with usually adequate amounts of choline, a deficiency state can be induced.

² Supported by U.S.P.H.S. research grants H-4089 and H-3525 from the National Heart Institute, Bethesda, Maryland.

Manuscript received 30 June 1961.