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Metabolic Interrelationships between Vitamin B₁₂ and Pantothenic Acid in the Rat¹

Central Food Technological Research Institute, Mysore, India

1. The elevation in hepatic coenzyme A in the vitamin B₁₂-deficient rat was attended by decreases in total soluble sulfhydryl, glutathione and total methionine. The changes were reversed and the levels returned to almost normal values within 48 hours after administration of a single dose of vitamin B₁₂.

2. Supplementation of a low-methionine diet with L-cysteine hydrochloride resulted in increases in liver stores of coenzyme A, total soluble sulfhydryl, glutathione and methionine, the rise in coenzyme A level being more in the vitamin B₁₂-deficient rat than in the supplemented one.

3. The vitamin B₁₂-deficient animal showed greater in vivo synthesis of coenzyme A from intraperitoneally administered precursors, than the vitamin-supplemented animal. Prior administration of vitamin B₁₂ to the deficient animal decreased the coenzyme A synthesis.

4. Administration of L-cysteine hydrochloride to rats deficient in both pantothenic acid and vitamin B₁₂ was without appreciable effect on the liver levels of coenzyme A, total soluble sulfhydryl, glutathione and methionine. Prior administration of pantothenic acid or of vitamin B₁₂ favored increased synthesis of coenzyme A or of total soluble sulfhydryl, glutathione and methionine, respectively.

Manuscript received 24 May 1961.