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Effect of Vitamin D on the Utilization of Zinc, Cadmium and Mercury in the Chick1

N. A. Worker2 and B. B. Migicovsky

Animal Research Institute, Research Branch, Canada Department of Agriculture, Ottawa, Ontario

Studies were reported on the effect of vitamin D on the metabolism of zinc, cadmium and mercury after administration of isotopes of these elements orally and subcutaneously to rachitic chicks.

The movement of zinc and cadmium from an oral dose into bone was significantly increased by vitamin D, (no such increase was found for mercury).

When zinc and cadmium were dosed subcutaneously, no difference in concentration of isotopes in bone between supplemented and nonsupplemented birds was observed.

These findings suggest that vitamin D may exert an effect on the metabolism of both zinc and cadmium and that the site of this effect is in the absorption mechanism.

Attention is drawn to the similarity of the results obtained with zinc and cadmium in these experiments and those obtained previously with calcium and other elements of the Group IIA series.

1 Contribution no. 72 from the Animal Research Institute, Research Branch, Canada Department of Agriculture, Ottawa, Canada.

2 Postdoctorate Fellow, National Research Council, Ottawa, Canada, 1960-61. Present address: Ruakura Animal Research Station, Private Bag, Hamilton, New Zealand.

Manuscript received 11 May 1961.


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