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Effect of Various Vitamin Deficiencies on Citric Acid Metabolism in the Rat¹

Department of Biochemistry, University of Wisconsin, Madison, Wisconsin

The effect of various vitamin deficiencies on urinary and tissue citrate levels has been compared with that of vitamin D deficiency. Pantothenic acid and vitamin B₆ deficiencies significantly depressed the levels of urinary, serum, and kidney citrate comparable to those found in vitamin D deficiency. They affected bone citrate only slightly, however, whereas vitamin D deficiency reduced this value greatly. Vitamin A and biotin deficiencies were essentially without effect. Although a severe thiamine deficiency depressed urinary citrate, this apparently was due to inanition, because with a mild though definite thiamine deficiency, as indicated by a reduction in pyruvate oxidation by kidney homogenates, urinary and tissue citrate values were unchanged.

Manuscript received 16 April 1961.