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Effects of Exercise and Reserpine Treatment on Heart Rate during Thiamine Deficiency in the Rat¹

Physiology Department, University of Ottawa, Ottawa, Ontario

The effects of ether, handling or spontaneous activity in rats all tend to obscure thiamine deficiency bradycardia by increasing the variability of heart rate. Conditions were described for the measurement of "resting" heart rate which has a low variability and may be used to detect thiamine deficiency at a relatively early stage. The extent to which the heart may accelerate above the resting level remained unimpaired in the early stages of thiamine deficiency bradycardia. AT the same time reserpine had a relatively greater heart slowing effect on the thiamine-deficient animal. It was argued that the autonomic regulating mechanisms, far from being the cause of the bradycardia, tended to compensate for it. Unexpectedly, reserpine caused an initial tachycardia in thiaminedeficient unanesthetized animals before the slowing phase. This was not noted in normal animals and was largely obscured by anesthesia.

Manuscript received 20 March 1961.