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The Biological Activities of 6-Methyl-7-chloro-9-(1'-D-ribityl)isoalloxazine and Dichlororiboflavin^1,2,3,

Department of Physiology, University of Rochester, School of Medicine and Dentistry, Rochester, New York

6-Methyl-7-chloro-9-(1'-D-ribityl)isoalloxazine has been found to be a potent inhibitor of riboflavin in the nutrition of Lactobacillus casei. It did not, however, inhibit the growth or metabolism of several clinically interesting or important micro-organisms.

This new flavin has been found to stimulate a small growth response in the riboflavin-deficient rat. When administered simultaneously with dietary riboflavin it interferes with the utilization of the latter and is, by virtue of this action, an inhibitor, although a relatively weak one.

The observation that dichlororiboflavin is inert for L. casei has been confirmed and it has been found to be inert in the nutrition of the riboflavin-deficient rat as well.

² Brief reference was made to a portion of this work at the Symposium on the Antimetabolites, Their Modes of Action and Therapeutic Implication, 10th Annual Meeting, The National Vitamin Foundation, Inc., New York, 1955.

³ 6-Methyl-7-chloro-9-(1'-D-ribityl)isoalloxazine has been screened for anticancer activity by the Cancer Chemotherapy National Service Center.

Manuscript received 16 March 1961.