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Glyoxalase Activity in Liver and Blood of Thiamine-Deficient Rats¹

Department of Pharmacology, School of Medicine, University of British Columbia, Vancouver, Canada

Pyruvaldehyde catabolism has been examined in liver and blood of normal and thiamine-deficient rats. Liver glyoxalase activity was reduced in thiamine-deficient animals and this was due to lowered glyoxalse I levels and probably decreased glutathione. Blood glyoxalase activity was lowered in thiamine deficiency and this appears to result from lowered glutathione levels alone. It is not known whether these changes are a direct result of a deficiency of the vitamin or a consequence of severely reduced food intake. Pyruvaldehyde could not be detected in the urine of deficient animals. The data presented are consistent with the idea that pyruvaldehyde metabolism is not an important factor in thiamine deficiency.

Manuscript received 25 January 1961.