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Journal of Nutrition Vol. 74 No. 3 July 1961, pp. 324-328
Copyright © 1961 by American Society for Nutrition
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Effects of 3:5:3'-Triiodo-D-Thyronine on Serum Vitamin A and Carotenoids in Hypothyroidism1

Agnes Horvat2 and Joseph M. Merrill

Departments of Biochemistry and Medicine, Vanderbilt University and Veterans Administration Hospital, Nashville, Tennessee

D-Triiodothyronine lowered serum carotenoids and cholesterol but did not change serum vitamin A consistently. Increased oxygen consumption occurred when D-T3 was given. No evidence was obtained that D-T3 enhanced conversion of ß-carotene to vitamin A.

The study with the thyroidectomized rats suggests that D-triiodothyronine did not increase the amount of liver vitamin A formed from carotene nor alter appreciably the excretion of carotene.

1 Taken in part from a thesis submitted in partial fulfillment for a degree of M.S. in Biochemistry.

2 Present address: Central Institute of Hygiene, Zagreb, Yugoslavia.

Manuscript received 25 January 1961.




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