Journal of Nutrition

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Journal of Nutrition Vol. 74 No. 3 July 1961, pp. 249-253
Copyright © 1961 by American Society for Nutrition
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Some Relationships between Caloric Restriction and Body Weight in the Rat

II. The Metabolism of Radioactive Glucose and the Activity of Some TPN-Linked Enzymes in the Liver1

Melvin Lee and S. P. Lucia

Department of Preventive Medicine, University of California School of Medicine, San Francisco, California

The relationship between caloric restriction (without concomitant weight loss) and glucose utilization has been investigated. Animals which have not been restricted show evidence of a direct oxidative pathway of glucose metabolism (hexose monophosphate pathway). Caloric restriction is accompanied by a decrease in the direct oxidation of glucose and when caloric restriction is sufficiently severe to cause weight loss the hexose monophosphate pathway disappears and is not re-established by a period of ad libitum feeding.

During caloric restriction the in vitro activity of 6-phosphogluconic acid dehydrogenase does not change but the activity of glucose-6-phosphate dehydrogenase increases about fourfold.

To what extent these changes are the underlying mechanisms of the caloric-restriction-adaptation is not clear but they may either cause or reflect a change in fat turnover and, thereby, an increase in the efficiency of food utilization.

1 Supported in part by a research grant A-3872 from the National Institutes of Arthritis and Metabolic Diseases, National Institutes of Health, Department of Health, Education and Welfare, a grant from the University of California School of Medicine, and a donation by Mr. and Mrs. Winston S. Cowgill, in memory of Charles A. Christenson.

Manuscript received 20 February 1961.




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