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Nitrogen Intake and Ribonuclease Activity in Normal and Tumor-Bearing Rats¹

Bureau of Biological Research, Rutgers University, New Brunswick, New Jersey

1. The RNA-phosphorus and protein content of the liver increased and the activity of ribonuclease decreased as casein nitrogen intake of normal rats was increased. The DNA-phosphorus content of the liver was independent of nitrogen intake.

2. There was an optimum intake of casein nitrogen for maximal growth of the Walker 256 carcinosarcoma transplanted into rats. The RNA-phosphorus was maximal and the ribonuclease activity of the tumor was minimal at the point of maximal growth of the tumor. The DNA-phosphorus was high in the tumor tissue and independent of the nitrogen intake.

3. The growth of the tumor at low-nitrogen intake resulted in a reduced RNA-phosphorus and an increased ribonuclease activity of the liver when compared with normal controls. The tumor had no effect upon DNA-phosphorus of the liver.

4. Lipemia associated with the growth of the tumor was maximal during maximal growth of the tumor.

Manuscript received 30 January 1961.