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Journal of Nutrition Vol. 74 No. 2 June 1961, pp. 167-170
Copyright © 1961 by American Society for Nutrition
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A Mechanism for the Copper-Molybdenum Interrelationship

II. Response of Liver Sulfide Oxidase Activity to Nutritional Factors1

Lewis M. Siegel and K. J. Monty

McCollum-Pratt Institute, The Johns Hopkins University, Baltimore, Maryland

The in vivo response of liver sulfide oxidase to a number of nutritional stimuli is reported. The decreased level of the enzyme accompanying molybdate toxicity was attributable largely to the decreased food intake of the animals. Evidence was presented to indicate a dependence of the enzyme upon copper and an adjustment of enzyme activity to substrate level. The results were discussed in terms of a postulated role for the enzyme in the induction of copper deficiency by toxic levels of molybdate.

1 Contribution no. 321 from the McCollum-Pratt Institute. Supported in part by a contract with the Division of Biology and Medicine, U. S. Atomic Energy Commission.

Manuscript received 25 January 1961.




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