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Journal of Nutrition Vol. 73 No. 4 April 1961, pp. 379-385
Copyright © 1961 by American Society for Nutrition
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Distribution and Excretion of F18 Fluoride in Beef Cattle1

M. C. Bell, G. M. Merriman and D. A. Greenwood

University of Tennessee-Atomic Energy Commission, Agricultural Research Laboratory, Oak Ridge, Tennessee, Animal Husbandry-Veterinary Science Department, University of Tennessee, Knoxville, Tennessee and Department of Chemistry, Utah State University, Logan, Utah

Blood, saliva, urine and fecal samples from two beef heifers and 12 mature beef cows given tracer levels of F18 showed that F18 was distributed and excreted rapidly. After 2 min., 53% of the dose remained in the blood, but after 240 min., only 4% of the dose remained in the blood. The F18 in the protein-free filtrate was higher than in the plasma or cells. Tissue samples taken at 240 min. after dosing showed high concentrations of F18 in lung, kidney, rumen wall, reticular wall and in bone. Continued feeding of fluoride did not influence metabolism or excretion of F18. Stable fluoride varied with the levels of fluoride fed.

1 This manuscript is published with the permission of the Director of the University of Tennessee Agricultural Experiment Station, Knoxville, Tennessee, and the Director of Utah Agricultural Experiment Station, Logan, Utah. The radioactive materials used in this work were obtained from the Oak Ridge National Laboratory on allocation from the United States Atomic Energy Commission. The work was completed under Contract no. AT-40-1-GEN-242 between the University of Tennessee College of Agriculture and the Atomic Energy Commission.

Manuscript received 29 September 1960.




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