Journal of Nutrition

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Journal of Nutrition Vol. 73 No. 4 April 1961, pp. 374-378
Copyright © 1961 by American Society for Nutrition
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The Effect of Niacin-Deficient, Tryptophan-Low and Protein-Deficient Diets on the DPN/DPNH Ratio in Mouse Liver1

M. A. Spirtes and Carl Alper

Departments of Pharmacology and Biological Chemistry, Hahnemann Medical College, Philadelphia, Pennsylvania

1. When compared with normal control animals, niacin-deficient mice developed the same percentage decrease of diphosphopyridine nucleotide (DPN) and DPNH liver values. This resulted in an unchanged DPN/DPNH ratio.
2. Protein-deficient mice developed a sharply lowered liver DPN content and an unchanged DPNH level; the DPN/DPNH ratio of this group was therefore markedly lowered compared with its control.

1 This investigation was supported by Grants A-2165 and B-730 from the National Institutes of Health, Bethesda, Maryland.

Manuscript received 8 November 1960.




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