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Relation of Serum Tocopherol Level to Nitrogen Retention, Creatine, Creatinine and Free Alpha Amino Acid Nitrogen Excretion in Premature Infants¹

Department of Pediatrics, University of Colorado Medical Center, Denver, Colorado

In a group of premature infants, aged 24 to 79 days, fed an evaporated milk formula without tocopherol supplementation, serum tocopherol levels ranging from 0.04 to 0.54 mg per 100 ml were observed. Tocopherol supplementation raised the serum tocopherol levels, but was without significant effect on nitrogen retention or upon the excretion coefficients of creatine, creatinine or -amino nitrogen.

These results suggest no indication for special dietary tocopherol supplementation in the premature infant in the first trimester of life.

² John and Mary Markle Foundation Scholar in Medical Sciences.

Manuscript received 2 November 1960.