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Lipemia and Experimental Hypertension in Rats

Bureau of Biological Research, Rutgers University, New Brunswick, New Jersey

Hypertension was induced in unilaterally nephrectomized rats by administration of desoxycorticosterone acetate and 1% of sodium chloride in the drinking water. The hypertensive rats developed hypertrophy of the heart, liver and kidney with a reduction in serum albumin. Serum cholesterol, phospholipid and the lipid migrating electrophoretically with alpha and beta globulins increased in the hypertensive rats. Hypertrophy of the kidney and the increase in serum lipids were greater in animals fed wheat gluten than in those fed casein. There was a small increase in serum cholesterol in rats with normal blood pressure but with unilateral nephrectomy. Hypertension was not produced in rats fed the protein-free diet although increases in serum lipids were associated with depletion in body proteins.

Manuscript received 14 October 1960.