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Effect of Feeding Alcohol-Soluble and Alcohol-Insoluble Soybean Phosphatides on Plasma Lipids and on Atheromatosis in Rabbits

Stuart, Florida

With rabbits fed cholesterol-supplemented chow, equicaloric amounts of the following were compared for their effect on atherogenesis: hydrogenated vegetable oil, alchohol-soluble and alchol-insoluble soybean phosphatides. After 4 months, no difference in atherogenesis was noted among animals of the three groups; the alcohol-insoluble phosphatides caused less hypercholesterolemia and less hyperphospholipemia than alcohol-soluble phosphatides or vegetable oil.

In a second experiment, rabbits were made atherosclerotic by cholesterol feeding. Subsequently the animals were fed chow, supplemented with alcohol-soluble, alcohol-insoluble phosphatides or with hydrogenated vegetable oil. Six months after cessation of cholesterol feeding, lesions and lipid deposits were equally severe in all three groups.

Manuscript received 4 October 1960.