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On the Function and Metabolism of Vitamin E

III. Vitamin E and Antioxidants in the Nutrition of the Rat¹

Division of Animal Nutrition, University of Illinois, Urbana, Illinois

It has been found that rats carried through resorption-gestation when fed vitamin E-deficient diets will respond in a second reproduction cycle to the antioxidants N,N'-diphenyl-p-phenylenediamine (DPPD) and 1,2-dihydro-6-ethoxy-2,2,4-trimethylquinoline (ethoxyquin), but not to butylated hydroxytoluene (BHT) nor acid-reduced ubiquinone (ubichromanol), by bearing live young.

In addition, following resorption-gestation due to vitamin E deficiency in the original dams, rats have been carried through two litters in the second generation when fed vitamin E-free diets containing DPPD.

The livers and carcasses of rats receiving DPPD, of control rats fed a stock diet, of vitamin E-deficient rats, of rats on ethoxyquin, and of rats receiving high levels of -tocopherol were all found to contain a material which reacts with ,'-dipyridyl and is usually assumed to be vitamin E.

However, it was found chromatographically that, in fact, while all animals contained a new reducing compound (compound X), only the animals given high levels of -tocopherol contained vitamin E in addition to compound X. When DPPD and ethoxyquin were fed, these compounds, in addition to the unknown compound X, were found chromatographically in the livers of the animals.

Manuscript received 22 August 1960.