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Effect of Dietary Fat and Biotin on the Oxalacetic Carboxylase Activity of Several Rat Tissues^1,2,

Department of Animal Husbandry and Nutrition, University of Florida, Gainesville, Florida

A study has been made of the effect of zero, 2 and 20% fat diets, with and without 3 µg of biotin per day, on growth and the oxalacetic carboxylase activity of the heart, liver and kidney of rats.

Growth was stimulated (P < 0.01) by the biotin and increasing levels of dietary fat.

The oxalacetic carboxylase activity was greater (P < 0.01) overall in the tissues of the rats that received biotin. Biotin stimulation was greatest in the liver of female rats fed the zero % and in males fed the zero and 2% fat diets. Increased activity due to biotin occurred in the kidney of all male rats, but only in the kidney of females fed the 20% fat diets. Biotin had no effect on the activity in the heart.

The rats fed the 20% fat diets had less (P < 0.01) oxalacetic carboxylase activity in the liver; fat level had no effect on activity in the heart and kidney.

The kidney had more (P < 0.01) overall activity than the heart and liver.

² Investigation supported in part by a grant-in-aid by the National Heart Institute, U. S. Public Health Service.

Manuscript received 25 July 1960.