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Effect of Feeding Vitamin K-Deficient Diets to Female Rats1

V. Chalam Metta and B. Connor Johnson

Division of Animal Nutrition, University of Illinois, Urbana, Illinois

The female rat was very much less susceptible to vitamin K deficiency than the male. This increased resistance of the female rat to vitamin K deficiency was not affected by the prevention of coprophagy, nor was it due to lower food intake or slower rate of growth, but was apparently the result of a true sex difference presumably under hormonal control.


1 These studies were supported, in part, under contract no. DA-49-007-MD-544, with the Office of the Surgeon General, Department of the Army. The opinions expressed in this publication are those of the authors and not necessarily those of the Department of the Army.

Manuscript received 6 August 1960.


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Toxicol PatholHome page
A. M. Allen, C. T. Hansen, T. D. Moore, J. Knapka, R. D. Ediger, and P. H. Long
Hemorrhagic Cardiomyopathy and Hemothorax in Vitamin K Deficient Mice
Toxicol Pathol, January 1, 1991; 19(4-2): 589 - 596.
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