Journal of Nutrition

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Journal of Nutrition Vol. 72 No. 3 November 1960, pp. 379-386
Copyright © 1960 by American Society for Nutrition
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Effect of Bile Acids on Plasma Cholesterol in the Mouse1

E. E. Howe, D. K. Bosshardt and J. W. Huff

Merck Institute for Therapeutic Research, Rahway, New Jersey

From studies carried out in the weanling mouse, it was concluded that:

1. Taurocholic acid is less hypercholesterolemic than cholic acid.
2. Acetylation of methyl cholate in the three and 7 poistions eliminates its hypercholesterolemic action.
3. Lithocholic acid exerts a hypocholesterolemic effect and neutralizes the action of hypercholesterolemic bile acids.
4. Chenodeoxycholic acid has much the same action as lithocholic acid while hyodeoxycholic is more effective than lithocholic or chenodeoxycholic acid in neutralizing the hypercholesterolemic effect of cholic acid.

1 Since the preparation of this manuscript hyodeoxycholic acid has been reported to reverse the effect of cholic acid in female mice and to prevent cholesterol accumulation in the liver and carcass (Beher, W. J., G. D. Baker and W. T. Anthony 1960 Effect of cholic and hyodeoxycholic acids on metabolism of exogenous cholesterol in mice. Proc. Soc. Exp. Biol. Med., 103: 385).

Manuscript received 24 June 1960.




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