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Antibiotics and Plasma Cholesterol in the Mouse

Merck Institute for Therapeutic Research, Rahway, New Jersey

1. Oxytetracycline and succinylsulfathiazole either alone or in combination cause an elevation of plasma cholesterol of weanling mice fed a diet containing a saturated fat, cholesterol and cholic acid. When cod liver oil, a polyunsaturated fat, was substituted for the saturated fat, oxytetracycline was without effect.

2. Chlortetracycline under identical conditions depressed plasma cholesterol.

3. When a highly unsaturated fat or mixture of highly unsaturated fatty acids was included in a cholesterol-cholic acidfree diet, chlortetracycline produced a marked hypocholesterolemic effect. In the presence of less highly unsaturated fats or fatty acids such as corn oil, corn oil plus lard, or linoleic acid, chlortetracycline exerted no effect on plasma cholesterol.