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The Antisterility Activity of Alpha-Tocohydroquinone in the Female Rat¹

Department of Biochemistry, University of Colorado School of Medicine, Denver, Colorado

The antisterility activity of -tocohydroquinone in vitamin E-deficient female rats has been re-examined.

For this purpose, the hydroquinone was prepared daily by the catalytic hydrogenation of -tocoquinone which was free of -tocopherol.

When injected at a level of 5 mg daily, the -tocohydroquinone exhibited antisterility activity. Smaller doses cured the muscle lesions in the mother but did not prevent fetal death and resorption.

Manuscript received 13 June 1960.