Journal of Nutrition OpenSOurce Diets- www.ResearchDiets.com

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

Journal of Nutrition Vol. 72 No. 3 November 1960, pp. 302-308
Copyright © 1960 by American Society for Nutrition
This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Morrison, M. A.
Right arrow Articles by Harper, A. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Morrison, M. A.
Right arrow Articles by Harper, A. E.

Amino Acid Balance and Imbalance

V. Effect of an Amino Acid Imbalance Involving Niacin on Liver Pyridine Nucleotide Concentration in the Rat1

Mary A. Morrison2 and May S. Reynolds

School of Home Economics

A. E. Harper

Department of Biochemistry University of Wisconsin, Madison, Wisconsin

The effects of an amino acid imbalance on growth and liver pyridine nucleotide concentrations of rats fed niacin-deficient diets containing 8% of casein have been determined. Growth depressions caused by adding threonine or 6% of gelation to the diet were prevented by niacin supplementation, but those caused by adding 12% of gelatin were not. Liver pyridine nucleotide concentrations were not low even when the growth depression was severe and were unaffected by niacin supplementation.

The growth depressions caused by threonine or gelatin were prevented by supplementation of the diet with tryptophan. A supplement of tryptophan caused a rise in liver pyridine nucleotide concentration when the imbalance was caused by threonine, but not when it was caused by gelatin.

The conclusion has been drawn from consideration of these results and those of other investigators that imbalances involving niacin and tryptophan are true amino acid imbalances comparable with those demonstrated in diets not deficient in niacin, and that the involvement of niacin is secondary.

1 Published with the approval of the Director of the Wisconsin Agricultural Experiment Station. Supported in part by grants from the Nutrition Foundation, Inc., New York and the National Institute of Arthritis and Metabolic Diseases, U. S. Public Health Service. Some of the crystalline vitamins were kindly provided by Merck Sharp and Dohme Research Laboratories, Rahway, New Jersey.

2 General Foods Fund Fellow in Home Economics. Present address: New York State College of Home Economics, Cornell University, Ithaca, New York.

Manuscript received 28 April 1960.




Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]