Journal of Nutrition

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Journal of Nutrition Vol. 72 No. 3 November 1960, pp. 293-296
Copyright © 1960 by American Society for Nutrition
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The Antithyrotoxic Factor of Liver

V. Failure of Thyrotoxicosis to Deplete the Activity in Swine Tissues

L. R. Overby and R. L. Fredrickson

Nutrition Research Department, Research Division, Abbott Laboratories, North Chicago, Illinois

Defatted commercial hog liver residue has promoted growth and survival of thyrotoxic rats, an effect not yet reproduced with known nutrients. In this experiment defatted muscle, defatted liver residue and liver fat were prepared from normal swine and swine made thyrotoxic with iodinated casein. In each case the tissue component from the thyrotoxic animals had a higher level of rat protective activity than that from normal swine. In both cases muscle tissue was about one half as active as liver. The results do not support the concept of a vitamin-like entity for the "antithyrotoxic factor."

Manuscript received 14 July 1960.




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