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The Biological Activity of 6-Chloro-7-Methyl-9-(1'-D-Ribityl)-Isoalloxazine^1,2,3,

Department of Physiology, University of Rochester, School of Medicine and Dentistry, Rochester, New York

1. It has been found that 6-chloro-7-methyl-9-(1'-D-ribityl)-isoalloxazine is a reversible antagonist of riboflavin in the nutrition of Lactobacillus casei with an inhibition index of 76.

2. This analog of riboflavin has also been found to be a reversible antagonist in the nutrition of the rat. The growth which is stimulated by low levels of this material is approximately equal to the growth stimulated by one-half the quantity of riboflavin. High levels of the analog are lethal to the animal if adequate amounts of riboflavin are not available.

² Brief reference to this work was made at the Symposium on the Anitmetabolites, Their Modes of Action and Therapeutic Implications, 10th Annual Meeting, The National Vitamin Foundation, Inc., New York, 1955.

³ This compound has been screened for anti-cancer activity by the Cancer Chemotherapy National Service Center.

Manuscript received 7 May 1960.