QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by McClure, F. J. Search for Related Content PubMed PubMed Citation Articles by McClure, F. J.

The Cariostatic Effect in White Rats of Phosphorus and Calcium Supplements Added to the Flour of Bread Formulas and to Bread Diets

National Institute of Dental Research, National Institutes of Health, Public Health Service, U. S. Department of Health, Education and Welfare, Bethesda, Maryland

A relatively simple diet composed of dry bread, glucose and essential vitamins, resulted in extensive dental caries in white rats.

In two trials, bread prepared with a flour which contained 1.0% of Na₂HPO₄ resulted in a reduced caries incidence averaging 51.0%; the severity score was reduced an average of 83.0%. Use of bread flour containing 1.0% (NH₄)₂HPO₄ was responsible for a 72.0% reduction in caries incidence and 93.0% reduction in severity score. These phosphates also significantly inhibited caries when added directly to bread diets. Ca(H₂PO₄)₂·H₂O at a level of 1.75% in the bread flour, and 1.5% Ca₃(PO₄)₂ in the bread-glucose diet significantly inhibited dental caries.

In two trials 1.41% of sodium phytate added to the bread-glucose diet reduced caries incidence an average 77.0% and caries severity score an average 91.0%.

Calcium lactate added to bread flour was anticariogenic, but calcium gluconate had no anticaries effect.

Three phosphate compounds, namely, Na₂HPO₄, Ca₃(PO₄)₂ and sodium phytate, were equally effective as phosphorus supplements as measured by improved rate of growth and increased content of blood-serum phosphorus.

These results add substantially to previous evidence of a significant cariostatic effect of a phosphated bread and a phosphate supplement added to a bread-glucose cariogenic diet.

This article has been cited by other articles:

				Alveolar Ridges The Journal of the Royal Society for the Promotion of Health, June 1, 1975; 95(3): 163 - 164.

				F. J. McClure Cariostatic Effect of Phosphates Science, June 12, 1964; 144(3624): 1337 - 1338. [Abstract] [PDF]