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The Effect of Pyridoxine on Cholesterol Metabolism¹

Department of Food Technology, University of Illinois, Urbana, Illinois

The effect of pyridoxine deficiency on the in vivo synthesis of cholesterol from acetate and mevalonic acid, and on the excretion of cholesterol-4-C¹⁴ via bile in bile cannulated rats was studied. The results indicated that pyridoxine deficiency enhanced the incorporation of labeled acetate into liver. It was shown that this enhanced incorporation of labeled acetate into cholesterol in deficient rats could be reversed by injecting pyridoxine hydrochloride. The synthesis of cholesterol from mevalonic acid, and excretion of cholesterol-4-C¹⁴ were not altered by pyridoxine deficiency.

² Portion of a thesis presented by S. N. Shah as partial fulfillment of the requirement for the degree of Doctor of Philosophy.

Manuscript received 29 April 1960.