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Journal of Nutrition Vol. 71 No. 2 June 1960, pp. 182-187
Copyright © 1960 by American Society for Nutrition
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The Biological Activity of 6-Ethyl-9-(1'-D-Ribityl)-Isoalloxazine1

J. P. Lambooy and H. V. Aposhian

Department of Physiology, University of Rochester, School of Medicine and Dentistry, Rochester, New York

It has been found that 6-ethyl-9-(1'-D-ribityl)-isoalloxazine has approximately 3% of the activity of riboflavin when used as the sole flavin in the nutrition of Lactobacillus casei.

This isomer of riboflavin has been found to be devoid of growth promoting activity in the riboflavin-deficient rat. It is a low-potency antagonist of riboflavin with an inhibition index of approximately 400.

1 This investigation was supported in part by a research grant no. CY 2940 from the National Cancer Institute of the Public Health Service.

Manuscript received 30 January 1960.




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