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The Response of Man to Dietary Cholesterol^1,2,

Departments of Biochemistry and Medicine, Queen's University, Kingston, Ontario

Ninety-three university students were placed upon a homogenized fat-free diet for a period of 8 days at which time they were divided into 8 groups and given a ration modified by the substitution of a butter-fat fraction, low in cholesterol, for 30% of calories at the expense of carbohydrate. Cholesterol supplements varying from nil up to 1600 mg/950 Cal. were added. Sixty-seven subjects successfully completed the experiment which was terminated after a total of 16 days. Between intakes of 13 and 634 mg of cholesterol per day, the serum cholesterol increased sharply but no further significant increases were obtained at daily intakes of 1300 to 4500 mg.

² Presented in abbreviated form at the meeting of the Council on Arteriosclerosis of the American Heart Association on November 8, 1959.

Manuscript received 28 December 1959.