Journal of Nutrition

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Journal of Nutrition Vol. 70 No. 4 April 1960, pp. 459-462
Copyright © 1960 by American Society for Nutrition
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Effects of Ethionine on Neonatally Castrated Male Rats1

Jerome A. Grunt2, James T. Higgins, Jr.3 and Charles B. Hammond

Departments of Anatomy and Pediatrics, Duke University School of Medicine, Durham, North Carolina

1. Massive fatty metamorphosis, equal to but not exceeding that found in the ethionine-treated adult castrated rat occurs in the neonatally-castrated animal treated with ethionine.
2. Liver function tests yield results which show more functional hepatic impairment in the neonatally-castrated rat treated with ethionine than in other groups.
3. Alterations in serum glutamic-pyruvic transaminase were statistically significant. It appears that the elevation of SGPT is a valid indicator of hepato-cellular injury.
4. Apparently the neonatally castrated male rat was most susceptible to ethionineproduced hepatic damage.

1 Aided in part by a grant from the Duke University Council on research and in part by U.S.P.H.S. Research Grant no. A-3053 (A).

2 This investigation was carried out during the tenure of a Special Fellowship from the National Institute for Arthritis and Metabolic Diseases, U.S.P.H.S. Dr. Grunt's present address is The Children's Hospital, Boston 15, Massachusetts.

3 During tenure of U.S.P.H.S. medical student research fellowship.

Manuscript received 4 September 1959.




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