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Potency of Vitamin K₁ and Two Analogues in Counteracting the Effects of Dicumarol and Sulfaquinoxaline in the Chick^1,2,

Department of Poultry Science, Rugers University, New Brunswick, New Jersey

When graded levels of vitamin K₁, menadione, or menadione sodium bisulfite complex were added to a vitamin K-deficient diet, 1 mg, 1.15 mg and 1.45 mg respectively, per kilogram of feed were required to obtain prothrombin times indicating an optimum level of plasma prothrombin. When the same compounds were fed with a diet containing 400 mg of dicumarol per kg, the requirement of the chicks appeared to be elevated to 1600 mg of vitamin K₁. Up to 8 times this level, on an equimolecular basis, of the two menadione compounds did not counteract the hypoprothrombinemic effect of dicumarol. When the diet contained 0.2% of sulfaquinoxaline, vitamin K₁ (4 mg/kg diet), as well as the two forms of menadione, counteracted most but not all of the hypoprothrombinemic effect of this drug.

² This research was supported in part by a grant from Hoffmann-La Roche, Inc., Nutley, N. J.

Manuscript received 28 September 1959.