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Pantothenic Acid Deficiency in the Young Guinea Pig^1,2,

Iowa Agricultural and Home Economics Experiment Station, Iowa State University, Ames

A pantothenic acid deficiency was produced in guinea pigs by feeding the antimetabolite, -methylpantothenic acid along with a natural ration. Except for the decreased concentration of ascorbic acid in the blood serum, the symptoms which were produced by feeding the analogue in this study, have been reported for one species or another as pantothenic acid deficiency. Physical symptoms observed in this experiment included soft woolly fur, pallor, lassitude, salivation, watering of the eyes, muscular weakness of the hind legs, convulsions and coma. Biochemical changes were characterized by anemia, accumulation of pyruvic acid in the blood and lowered serum ascorbic acid levels. Hemorrhagic adrenals and splenomegaly were observed upon autopsy. The deficiency was believed to have been chronic.

² Presented at the meetings of the American Institute of Nutrition, Atlantic City, New Jersey, April, 1956.

³ Present address: Home Economics Department, University of Missouri.

Manuscript received 5 October 1959.