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The Effect of Scurvy on Thyroid Activity in the Guinea Pig¹

Department of Nutrition, School of Hygiene, and Department of Pathological Chemistry, Banting Institute, University of Toronto, Toronto, Ontario

Using a purified diet of known composition, it has been possible to substantiate earlier reports of an increased oxygen uptake by scorbutic guinea pigs. It was also demonstrated that these animals showed increased thyroidal uptake of I¹³¹. The evidence indicates that thyroid activity is increased in scurvy in the guinea pig. This increased activity may be linked to the abnormal metabolism of tyrosine, a thyroid hormone precursor, in scurvy. Female guinea pigs are more susceptible to scurvy than are males, perhaps owing to a higher requirement of a lower initial store of the vitamin.

Manuscript received 14 September 1959.

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