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Further Studies of the Lipotropism of Diethylstilbestrol in Choline-Deficient Weanling Albino Rats¹

Division of Agricultural Biochemistry, University of Wyoming, Laramie

The concentration of dietary diethylstilbestrol (DES) that most effectively reduced liver lipide accumulation in choline-deficient rats was much higher than the concentration required to prevent illness and death.

The growth depression caused by 0.1 and 10 ppm of DES was essentially the same, but the liver lipide accumulation in choline-deficient rats receiving 0.1 ppm of DES was considerably larger than that of rats receiving 10 ppm.

The increased unsaturation in the liver lipide of choline-deficient rats appeared to be due to a higher content of dienoic fatty acids, which made up approximately 60% of the dietary lipide.

The presence of dietary DES significantly reduced the adrenal cholesterol content in rats when this value was compared to that of rats receiving no DES. This was true for both choline-deficient and choline-supplemented rats.

Manuscript received 14 July 1959.