QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Self, H. L. Articles by Price, J. M. Search for Related Content PubMed PubMed Citation Articles by Self, H. L. Articles by Price, J. M.

Quantitative Studies on the Metabolites of Tryptophan in the Urine of Swine^1,2,

Department of Animal Husbandry, College of Agriculture and the Cancer Research Hospital, Medical School, University of Wisconsin, Madison, Wisconsin

The urinary excretion of tryptophan metabolites by growing swine was determined before and after the administration of 0.5 and 1.0 gm supplements of L-tryptophan.

Kynurenine, 3-hydroxykynurenine, kynurenic acid and xanthurenic acid, which had been found major urinary metabolites of tryptophan in man, the dog and the rat proved to be minor metabolites of the amino acid in swine. The growing pigs excreted large quantities of N-acetylkynurenine, o-aminohippuric acid, anthranilic acid glucuronide and an unknown diazotizable amine.

When swine were given supplements of tryptophan, no significant change was found in the urinary excretion of N-methyl-2-pyridone-5-carboxamide, although this metabolite appeared in relatively large quantities following the administration of 400 mg of nicotinamide.

² Published with approval of the Director of the Wisconsin Agricultural Experiment Station.

³ American Cancer Society—Charles S. Hayden Foundation Professor of Surgery in Cancer Research.

Manuscript received 13 July 1959.