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Journal of Nutrition Vol. 70 No. 1 January 1960, pp. 100-102
Copyright © 1960 by American Society for Nutrition
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An Effect of Dietary Sulfate on Selenium Poisoning in the Rat1

A. W. Halverson2 and K. J. Monty

McCollum-Pratt Institute, The Johns Hopkins University, Baltimore, Maryland

Dietary sulfate was shown to restore partially the growth of selenized rats receiving a purified diet with selenium added as selenite or as selenate. Sulfate levels of 0.29, 0.58 and 0.87% as sodium or as potassium salts progressively relieved the growth inhibition due to selenium. Alleviations of greater than 40% were observed. Sulfate, however, did not substantially prevent liver degeneration due to selenium.

1 Contribution no. 266 from the McCollum-Pratt Institute. Supported in part by a contract with the U. S. Atomic Energy Commission and a grant from the National Institutes of Health.

2 Fellow of the National Institutes of Health, on leave from Station Biochemistry, South Dakota State College, Brookings.

Manuscript received 10 August 1959.




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