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An Effect of Dietary Sulfate on Selenium Poisoning in the Rat¹

McCollum-Pratt Institute, The Johns Hopkins University, Baltimore, Maryland

Dietary sulfate was shown to restore partially the growth of selenized rats receiving a purified diet with selenium added as selenite or as selenate. Sulfate levels of 0.29, 0.58 and 0.87% as sodium or as potassium salts progressively relieved the growth inhibition due to selenium. Alleviations of greater than 40% were observed. Sulfate, however, did not substantially prevent liver degeneration due to selenium.

² Fellow of the National Institutes of Health, on leave from Station Biochemistry, South Dakota State College, Brookings.

Manuscript received 10 August 1959.

This article has been cited by other articles:

				O.E. Olson Selenium Toxicity in Animals with Emphasis on Man International Journal of Toxicology, January 1, 1986; 5(1): 45 - 70. [Abstract] [PDF]