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The Use of Casual Urine Specimens in the Evaluation of the Excretion Rates of Thiamine, Riboflavin and N¹-Methylnicotinamide

United States Army Medical Research and Nutrition Laboratory, Fitzsimons Army Hospital, Denver, Colorado

A man's urinary excretion of thiamine or riboflavin per 6 hours can be predicted from the excretion per gram of creatinine within limits of plus or minus 30 to 40%. The limits are larger for N¹-methylnicotinamide. The predictability is affected by variations in body size, by diurnal variations in creatinine excretion, and by dietary intake of creatinine. The predictability is more accurate with fasting urine specimens. It is concluded, however, that for surveys of large groups of individuals the measurement of vitamin excretion rate per gram of creatinine in casual urine specimens is a satisfactory procedure in the biochemical evaluation of nutritional status.