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Serum Protein Changes in Vitamin E-Deficient Chicks

Laboratory of Nutrition and Endocrinology, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland

Concomitant with the onset of exudates in chicks fed a diet deficient in vitamin E and selenium, changes occurred in the electrophoretic patterns of the serum proteins. The decrease in albumin: globulin ratio did not appear to be of sufficient magnitude to account for the edema. Total serum proteins declined only slightly, if at all. The most marked alterations in protein patterns developed after the chicks had spontaneously recovered, when increases in ₂-, ₃-, ß-, and -globulins occurred. The serum protein patterns in deficient chicks were sometimes restored to normal without the administration of vitamin E or selenium.