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Effect of Thiamine Deficiency and Thiamine Injection on Total Liver Lipids, Phospholipid, Plasmalogen and Cholesterol in the Rat¹

Department of Biochemistry and Nutrition, School of Medicine, University of North Carolina, Chapel Hill

The response of total liver lipids, phospholipid, plasmalogens, and cholesterol to thiamine deficiency has been studied in the rat. As expected, neutral lipid, except for cholesterol, fell rapidly to well below the normal control levels. Phospholipids were mainly unaffected during the deficiency, and plasmalogens showed a tendency to be maintained at a high level regardless of the deficiency. Cholesterol was higher in thiamine-deficient rat liver than in the normal controls. The sudden reintroduction of thiamine by injection caused total lipids to rebound to a high normal level and cholesterol, when expressed in terms of body weight, to reach a level almost twice that of normal. Phospholipids and plasmalogens followed patterns after thiamine injection that can be explained in terms of the maintenance of important cellular components that resist dietary changes.

² On leave, Department of Biochemistry, College of Agriculture, University of Wisconsin, Madison.

Manuscript received 23 April 1959.