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Interrelation of Cholesterol, Palmitic Acid, and Unsaturated Fatty Acids in the Growing Mouse and Rat¹

Merck Institute for Therapeutic Research, Rahway, New Jersey

Weanling male mice grow well on a purified diet containing 20% of palmitic acid and 1% of cholesterol, but succumb or fail to grow when 0.1% of oleic acid is added to the diet. Further addition of as little as 0.1% of this acid again affords good growth and survival.

If 0.1% of linoleic acid is incorporated into the diet, the critical lethal level of oleic acid becomes 0.8% and again increasing the oleic acid fed affords survival and a rapid rate of growth.

Mature male mice and weanling male rats survive on these diets but lose weight or grow very poorly.

A high percentage of weanling female mice succumb on a diet containing 20% of palmitic acid with or without cholesterol but survive when unsaturated fatty acids are added to their diets.

Manuscript received 10 November 1958.