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Serial Determinations of Serum Protein-bound Carbohydrates and Proteins During Protein Depletion and Repletion in the Adult Rat¹

Department of Infectious Diseases, School of Medicine, University of California Medical Center, Los Angeles

Serial determinations of the protein-bound carbohydrates and proteins of serum and of the seromucoid, albumin, and globulin fractions as well as the hemoglobin and hematocrit values of blood were made during the course of protein depletion, repletion and 4 weeks following repletion of the adult rat. Weight depletion to 25% was accompanied by significant decreases in all serum values. Severe depletion (40%) elicited variable responses; the seromucoid and albumin fractions were restored to normal while the serum globulins declined further. At repletion, all serum constituents were in the normal range or increased with the exception of albumin polysaccharide. Following repletion, the concentrations of the components of the albumin fraction decreased. Other serum constituents remained in the normal range or increased. Some of the elevation was attributable to increased age and weight. Hemoconcentration (10% depletion) was followed by hemodilution during further depletion and in repletion. Four weeks following repletion, hemoglobin and hematocrit values were normal. Hemoglobin was restored at a slower rate than were the serum glycoproteins or proteins.

Manuscript received 7 April 1959.