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Journal of Nutrition Vol. 69 No. 1 September 1959, pp. 18-22
Copyright © 1959 by American Society for Nutrition
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Vitamin K Deficiency in Rats Induced by the Feeding of Irradiated Beef1

V. Chalam Metta, M. S. Mameesh and B. Connor Johnson

Division of Animal Nutrition, University of Illinois, Urbana

Consumption of diets containing gamma-ray irradiated (2.79 or 5.58 x 104 rad) beef resulted in internal hemorrhages and prolonged prothrombin times in growing male rats. Generally the female rat did not show this syndrome. The lesion was induced by freshly irradiated beef as well as irradiated beef which has been stored for over 6 months at room temperature.

Supplementation with vitamin K prevented the hemorrhagic diathesis in rats consuming irradiated beef.

1 These studies were supported in part under contract no. DA-49-007-Md-544, with the Office of the Surgeon General, Department of the Army. The opinions expressed in this publication are those of the authors and not necessarily those of the Department of the Army.

Manuscript received 7 March 1959.




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