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The Domestic Cat as a Laboratory Animal for Experimental Nutrition Studies

VII. Pyridoxine Deficiency

Department of Physiology, Faculdade de Medicina da Universidade de S. Paulo, ^,4 S. Paulo, Brasil

Pyridoxine deficiency was obtained in growing cats. The signs observed were growth depression, microcytic hypochromic anemia with high serum iron, convulsive seizures and kidney lesions, represented by areas of tubular atrophy and tubular dilatation, fibrosis and intratubular deposition of birefringent crystalline material. The pyridoxine levels in tissues were reduced to approximately 50% of the control values. Xanthurenic acid excretion was very low, even after tryptophan load. Blood and plasma volume, total body water, blood glucose, pyruvic and lactic acid, plasma potassium, sodium, calcium and inorganic phosphorus were not affected. Satisfactory body weight and hematologic recoveries were obtained with pyridoxine treatment but the kidney lesions were not reversible.

² Now at the Department of Pharmacology, Faculdade de Medicina da Univ. de S. Paulo, Brasil.

³ Present address: Northwestern University Medical School; 301 E. Chicago Ave., Chicago.

⁴ Head, Prof. F. A. de Moura Campos.

Manuscript received 16 November 1958.