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The Effect of Dietary Fat on the Development of Vitamin B₆ Deficiency in the Rat^1,2,

Department of Nutrition and Home Economics, University of California, Berkeley

The effect of the level of dietary fat on the development of vitamin B₆ deficiency and on the body composition of vitamin B₆-deficient and pair-fed control rats was studied with diets in which the ratio of protein/food energy remained constant as the level of fat increased. In both deficient and control animals, the percentage of body fat increased as the percentage of dietary fat increased. Whether vitamin B₆ deficiency reduced body fat depended upon the level of dietary fat: there was no significant difference between the deficient and control groups at 5 or 40% of cottonseed oil, but a significant decrease occurred in the deficient animals fed a 10 or 20% of cottonseed oil diet. Vitamin B₆ deficiency also decreased the storage of liver cholesterol in cholesterol-fed rats.

² Presented in part before the American Institute of Nutrition at the 48th meeting of the Federation of American Societies for Experimental Biology at Chicago, April 15–19, 1957.

Manuscript received 20 August 1958.