Journal of Nutrition OpenSOurce Diets- www.ResearchDiets.com

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

Journal of Nutrition Vol. 68 No. 1 May 1959, pp. 109-120
Copyright © 1959 by American Society for Nutrition
This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sievert, A. H.
Right arrow Articles by Phillips, P. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sievert, A. H.
Right arrow Articles by Phillips, P. H.

Metabolic Studies on the Sodium Fluoride-Fed Rat1

Alice H. Sievert2 and Paul H. Phillips

Department of Biochemistry, University of Wisconsin, Madison

Fat metabolism in the rat was studied in a series of experiments designed to determine the effects of fluoride toxicosis upon fatty acid oxidase activity, on fat utilization and on the acetylation capacity of the intact rat.

1. Mitochondrial fatty acid oxidase activity was unaffected in the liver but was strikingly decreased in the kidney of the fluorotic rat. Concurrent changes in the kidney were a decrease in the fat and nitrogen content, and hypertrophy of the organ (wet wt.).
2. The decreased growth of ad libitum-fed fluorotic rats receiving a 15% fat diet, as compared with those receiving a 5% fat diet, was confirmed. However, when the caloric intake was held the same in rats given diets varying in fat content but identical in fluorine content, growth was the same in all groups. Fluorotic rats which were pair-fed isocaloric diets with their controls, were retarded in their rate of gain in weight.
3. Fluoride-fed rats excreted more fecal fat, nitrogen and dry matter than the control animals. The decreased retention of these nutrients could not be ascribed to an increase in intestinal motility or to starvation per se.
4. Dietary fluoride did not interfere with the acetylation of p-aminobenzoic acid by the intact rat. This suggests that the utilization of coenzyme A in this acetylation reaction, and presumably in those of fat metabolism, was not inhibited in the fluorotic rat.

1 Published with the approval of the director of the Wisconsin Agricultural Experiment Station. Supported in part by a grant from the Aluminum Company of America, Pittsburgh, Pennsylvania, on behalf of itself and the Aluminum Laboratories, Ltd., American Smelting and Refining Company, Kaiser Aluminum and Chemical Corporation, the Monsanto Chemical Company, the Reynolds Metals Company, the Tennessee Valley Authority, the U. S. Steel Corporation of Delaware, Ormet Corporation, American Cyanamid Company and Westvaco Chemical Division of Food Machinery and Chemical Corporation.

2 This study was in partial fulfilment of the requirements for the degree of doctor of philosophy in Biochemistry.

Manuscript received 29 October 1958.




Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]