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Journal of Nutrition Vol. 67 No. 4 April 1959, pp. 581-588
Copyright © 1959 by American Society for Nutrition
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The Effects of Long-Time Administration of Small Amounts of Fluoride in Food or Water on Caries-Susceptible Rats1

R. E. Wuthier and P. H. Phillips

Department of Biochemistry, University of Wisconsin, Madison

The long-term effects of low dosages of F- (fluoridation range) in both food and water are reported. Fluoride accumulated in the femur from all dietary levels, including the controls (0.5 p.p.m. F-). The quantity of F- stored was proportional to the level given. At equivalent levels water-borne F- storage was about double that from food-borne F-, but when corrections were made for total F- consumption, no great difference in retention was demonstrated. These concentrations of F- did not alter the dental score of the exposed rats. Growth rate, mature weight, reproduction, lactation, and general health of the rats were normal and unaffected by these amounts of F-. In this study the female rats consistently accumulated a higher concentration of femur F- than the males.

1 Published with the approval of the Director of the Wisconsin Agricultural Experiment Station, Madison. This work was supported in part by the Research Committee of the Graduate School from funds supplied by the Wisconsin Alumni Research Foundation. We are indebted to Merck and Company for the vitamins used in these studies.

Manuscript received 29 September 1958.




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