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The Domestic Cat as a Laboratory Animal for Experimental Nutrition Studies

VI. Choline Deficiency

Department of Physiology, Faculdade de Medicina da Universidade de S. Paulo, ^,3 S. Paulo, Brasil

Fatty livers were produced in growing cats after 8 weeks of subsistence on a diet containing 42% casein and 24% hydrogenated coconut fat; the fatty infiltration was not influenced by feeding supplements of 10% raw beef liver or 10% raw beef pancreas. Choline to the extent of 0.1% was ineffective as a lipotropic agent but did produce a mild growth response; 0.5% choline caused an appreciable reduction in the fatty infiltration and improvement in the growth rate. The deposition of fat was principally in the periportal spaces and not around the centrolobular vein as usually described for choline deficiency in other species.

² Assistant to Prof. Adriano Pondé, Faculdade de Medicina da Bahia, Brasil; on a fellowship at the Department of Gastroenterology; head, Dr. J. Fernandes Pontes. Hospital das Clínicas, Faculdade de Medicina da Universidade de S. Paulo; deceased, October 9, 1958.

³ Head, Prof. Franklin A. de Moura Campos.

Manuscript received 16 September 1958.