Journal of Nutrition

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Journal of Nutrition Vol. 67 No. 4 April 1959, pp. 525-530
Copyright © 1959 by American Society for Nutrition
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Production of Biotin Deficiency in the Guinea Pig1

Macie Collins Coots, A. E. Harper and C. A. Elvehjem

Department of Biochemistry, University of Wisconsin Madison

Guinea pigs were fed a biotin-deficient diet containing raw egg white as the source of protein. The following symptoms were observed: loss of weight, alopecia, and decoloration of the fur. These symptoms were cured by biotin supplementation.

1 Published with the approval of the Director of the Wisconsin Agricultural Experiment Station. Some of the crystalline vitamins were kindly provided by Merck Sharp and Dohme Laboratories, Rahway, New Jersey.

Manuscript received 10 September 1958.




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