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Journal of Nutrition Vol. 67 No. 1 January 1959, pp. 29-39
Copyright © 1959 by American Society for Nutrition
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Some Effects Related to the Potassium and Lysine Intake of Rats1

S. N. Gershoff, E. Coutino-Abath2, I. Antonowicz, A. L. Mayer, G. S. H. Shen and S. B. Andrus

Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts

The effect of feeding diets containing 0.14 and 0.72% of potassium and varying levels of lysine to rats has been studied. Partial protection against hair loss and increased liver fat were observed when the higher potassium level was fed to lysine-deficient rats, indicating an increased potassium requirement in these animals. Variations in the lysine but not the potassium content of the diets resulted in marked changes in the potassium and sodium content of skin but not of liver or muscle. The results of amino acid analyses and histologic studies of tissues from these animals have also been reported.

1 Supported in part by grants-in-aid from the National Institute of Arthritis and Metabolism (Grant no. A-1540), Public Health Service, National Institutes of Health, Bethesda, Maryland and the Fund for Research and Teaching, Department of Nutrition, Harvard School of Public Health.

2 Holder of a fellowship from the W. K. Kellogg Foundation and from the National Research Council of Brazil. Present address: Centro de Pesquisas Aggew Magalhães do Departmento, Nacional de Endemias Rurais and Department of Pathology, University of Recife Medical School, Recife, Brazil.

Manuscript received 22 July 1958.




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