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Journal of Nutrition Vol. 66 No. 3 November 1958, pp. 361-366
Copyright © 1958 by American Society for Nutrition
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Effect of Folic Acid Deficiency on Myoglobin Concentration in Skeletal Muscle of the Guinea Pig1,2,

Willard R. Faulkner3, Frank R. Blood and William J. Darby

Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee

In guinea pigs there occurred an unexpected increase in myoglobin content in the skeletal muscle of folic acid-deficient animals compared to pair-fed controls. In this species, the change in myoglobin was associated with a typical folic acid deficiency anemia and alteration in the hematologic picture. Possible implications of this finding for the existence of important differences in the synthesis or rate of degradation of myoglobin and hemoglobin are discussed.

1 The material presented in this paper is taken from a thesis submitted by Willard R. Faulkner in partial fulfillment of the requirements for the degree of Doctor of Philosophy from Vanderbilt University.

2 This work was supported in part by USPHS grant A-147 and from an S. E. Massengill grant.

3 Present address: Department of Clinical Pathology, Cleveland Clinic Foundation, Cleveland 6, Ohio.

Manuscript received 10 May 1958.




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